• Product NameALK inhibitor 2
• Brief DescriptionInhibitors
• Purification99.77%
• Biological ActivityALK inhibitor 2 is a novel and selective inhibitor for the ALK kinase.
• Target NameALK inhibitor
• CAS No. 761438-38-4
• Calculated MW 518.03
• Formulation C23H28ClN7O3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CNS(=O)(=O)C1=CC=CC=C1NC1=NC(NC2=C(OC)C=C(C=C2)N2CCN(C)CC2)=NC=C1Cl
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:ALK
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10 mM
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. A Dose Finding Study With Oral LDK378 in Patients With Tumors Characterized by Genetic Abnormalities in Anaplastic Lymphoma Kinase (ALK).

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting