• Product NameNSC 42834
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityNSC 42834(JAK2 Inhibitor V, Z3), a novel specific inhibitor of Jak2, inhibits Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner but was not cytotoxic to cells at concentrations that inhibited kinase activity.
• Target NameJAK inhibitor
• CAS No. 195371-52-9
• Calculated MW 344.45
• Formulation C23H24N2O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC(CCC1=CC=CC=N1)(CCC1=CC=CC=N1)C(=O)C1=CC=CC=C1
  Pathways:Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
  Receptor:JAK2; JAK2 (V617F)
  Boling pt:
  Melting pt:
  Solubility:DMSO: 43 mg/mL
  Appearance:Liquid
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Jacqueline Sayyah, et al. Mol Y Ther 2008;7(8):2308-18.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting