• Product NameTeriflunomide
• Brief DescriptionInhibitors
• Purification99.76%
• Biological ActivityTeriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio? and is indicated for the treatment of multiple sclerosis, specifically relapsing forms.
• Target NameDehydrogenase inhibitor
• CAS No. 108605-62-5
• Calculated MW 270.21
• Formulation C12H9F3N2O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Metabolism system
  SMILES:C/C(=C(\C#N)/C(=O)NC1=CC=C(C=C1)C(F)(F)F)/O
  Pathways:Metabolism
  Receptor:Dihydroorotate Dehydrogenase
  Boling pt:
  Melting pt:
  Solubility:Ethanol: ,1 mg/mL ,1; Water: <1 mg/mL (<1 mM); DMSO: 32 mg/mL (118.42 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Palmer AM. Curr Opin Investig Drugs. 2010 Nov;11(11):1313-23.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting