• Product NameTPCA-1
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityTPCA-1 is potent, selective inhibitor of IKK-2 (IC50 = 17.9 nM) that displays > 22-fold selectivity over IKK-1 and > 550-fold selectivity over others kinases and enzymes.
• Target NameIκB/IKK inhibitor
• CAS No. 507475-17-4
• Calculated MW 279.29
• Formulation C12H10FN3O2S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:C1=CC(=CC=C1C2=CC(=C(S2)NC(=O)N)C(=O)N)F
  Pathways:NF-κb
  Receptor:IKK2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 56 mg/mL (200.5 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Patricia LP, et al. JPET January 2005 vol. 312 no. 1 373-381

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting