• Product NameCZC-25146?
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityCZC-25146 is a potent, selective and metabolically stable LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2(Leucine-rich repeat kinase-2) and G2019S LRRK2 respectively.
• Target NameLRRK2 inhibitor
• CAS No. 1191911-26-8
• Calculated MW 488.54
• Formulation C22H25FN6O4S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:COC1=C(C=CC(=C1)N2CCOCC2)NC3=NC=C(C(=N3)NC4=CC=CC=C4NS(=O)(=O)C)F
  Pathways:Autophagy
  Receptor:G2019S LRRK2; LRRK2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 46 mg/mL
  Appearance:Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Ramsden N, et al. ACS Chem Biol. 2011 Oct 21;6(10):1021-8.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting