• Product NameUNC1999
• Brief DescriptionInhibitors
• Purification99.49%
• Biological ActivityUNC1999 is a potent, orally bioavailable and selective inhibitor of EZH2 and EZH1 with IC50 of 2 nM and 45 nM in cell-free assays, respectively, showing >1000-fold selectivity over a broad range of epigenetic and non-epigenetic targets.
• Target NameHistone Methyltransferase inhibitor
• CAS No. 1431612-23-5
• Calculated MW 569.74
• Formulation C33H43N7O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CCCC1=C(CNC(=O)C2=C3C=NN(C(C)C)C3=CC(=C2)C2=CN=C(C=C2)N2CCN(CC2)C(C)C)C(=O)NC(C)=C1
  Pathways:Chromatin/Epigenetic
  Receptor:EZH1; EZH2
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 100 mg/mL (175.51 mM); DMSO: 100 mg/mL (175.51 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Konze KD, et al. ACS Chem. Biol. 2013, 8 (6), 1324C1334.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting