• Product NameSMI-4a
• Brief DescriptionInhibitors
• Purification99.44%
• Biological ActivitySMI-4a is a potent inhibitor of Pim1 with IC50 of 17 nM, modestly potent to Pim-2, does not significantly inhibit any other serine/threonine- or tyrosine-kinases.
• Target NamePim inhibitor
• CAS No. 438190-29-5
• Calculated MW 273.23
• Formulation C11H6F3NO2S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C1=CC(=CC(=C1)C(F)(F)F)/C=C\2/C(=O)NC(=O)S2
  Pathways:Chromatin/Epigenetic; JAK/STAT signaling
  Receptor:Pim1
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 32 mg/mL (117.11 mM); DMSO: 55 mg/mL (201.29 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Beharry Z, et al. Mol Y Ther, 2009, 8(6), 1473-1483.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting