• Product NameAP26113
• Brief DescriptionInhibitors
• Purification97.66%
• Biological ActivityAP26113 is a potent ALK inhibitor with IC50 of 0.62 nM in a cell-free assay, demonstrated ability overcome Crizotinib resistance mediated by a L1196M mutation. Phase 2.
• Target NameALK inhibitor; EGFR inhibitor; IGF-1R inhibitor
• CAS No. 1197958-12-5
• Calculated MW 529.01
• Formulation C26H34ClN6O2P
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:COC1=C(NC2=NC=C(Cl)C(NC3=CC=CC=C3P(C)(C)=O)=N2)C=CC(=C1)N1CCC(CC1)N(C)C
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors; JAK/STAT signaling
  Receptor:ALK; EGFR (C797S/del19); EGFR (del19); EGFR (del19); IGF-1R
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 106 mg/mL (200.37 mM); DMSO: 45 mg/mL (85.06 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Sen Zhang, et al. Y Research: April 15, 2010; Volume 70, Issue 8, Supplement 1

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting