• Product NameFasudil (HA-1077) hydrochloride
• Brief DescriptionInhibitors
• Purification99.98%
• Biological ActivityFasudil hydrochloride(HA-1077; AT-877) is a potent inhibitor of ROCK-II, PKA, PKG, PKC, and MLCK with Ki of 0.33 μM, 1.6 μM, 1.6 μM, 3.3 μM and 36 μM, respectively.
• Target NamePKA inhibitor; PKC inhibitor; ROCK inhibitor; Serine/threonin kinase inhibitor
• CAS No. 105628-07-7
• Calculated MW 327.83
• Formulation C14H18ClN3O2S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:Cl.Cl.O=S(=O)(N1CCCNCC1)C1=CC=CC2=C1C=CN=C2
  Pathways:Cell Cycle/Checkpoint; Apoptosis; Cytoskeletal Signaling; GPCR/G Protein; Stem Cells
  Receptor:PKA; PKG; PKC; ROCK2; MLCK
  Boling pt:
  Melting pt:220.5˚C
  Solubility:Water: 65 mg/mL (198.27 mM); DMSO: 5 mg/mL (15.25 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Ono-Saito N, et al. Pharmacol Ther, 1999, 82(2-3), 123-131.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting