• Product NamePD-173955
• Brief DescriptionInhibitors
• Purification99.28%
• Biological ActivityPD173955 is a potent Bcr-Abl inhibitor with IC50 of 1-2 nM, also inhibiting Src activity with IC50 of 22 nM.
• Target NameBcr-Abl inhibitor; Src inhibitor
• CAS No. 260415-63-2
• Calculated MW 443.35
• Formulation C21H16Cl2N4OS
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CSC1=CC=CC(NC2=NC=C3C=C(C(=O)N(C)C3=N2)C2=C(Cl)C=CC=C2Cl)=C1
  Pathways:Angiogenesis; Cytoskeletal Signaling
  Receptor:Bcr-Abl; Src
  Boling pt:
  Melting pt:
  Solubility:DMSO: 15 mg/mL warmed (33.83 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Wisniewski D, et al. Y Res. 2002, 62(15), 4244-4255.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting