• Product NameTideglusib
• Brief DescriptionInhibitors
• Purification98.89%
• Biological ActivityTideglusib is an irreversible, non ATP-competitive GSK-3β inhibitor with IC50 of 60 nM in a cell-free assay; fails to inhibit kinases with a Cys homologous to Cys-199 located in the active site. Phase 2.
• Target NameGSK-3 inhibitor
• CAS No. 865854-05-3
• Calculated MW 334.39
• Formulation C19H14N2O2S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:O=C1SN(C(=O)N1CC1=CC=CC=C1)C1=CC=CC2=CC=CC=C12
  Pathways:PI3K/Akt/mTOR signaling; Stem Cells
  Receptor:GSK-3β
  Boling pt:
  Melting pt:
  Solubility:DMSO: 1 mg/mL (2.99 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Domnguez JM, et al. J Biol Chem, 2012, 287(2), 893-90

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting