• Product NameAZD1480
• Brief DescriptionInhibitors
• Purification97.50%
• Biological ActivityAZD1480 is a novel ATP-competitive JAK2 inhibitor with IC50 of 0.26 nM in a cell-free assay, selectivity against JAK3 and Tyk2, and to a smaller extent against JAK1. Phase 1.
• Target NameJAK inhibitor
• CAS No. 935666-88-9
• Calculated MW 348.77
• Formulation C14H14ClFN8
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC1=CC(=NN1)NC2=NC(=NC=C2Cl)N[C@@H](C)C3=NC=C(C=N3)F
  Pathways:Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
  Receptor:JAK2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 69 mg/mL warmed (197.83 mM)
  Appearance:Faint Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. E Derenzini, et al. Blood Y J, 2011, 1(12), e46.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting