• Product NameGANT61
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivityGANT61 is an inhibitor for GLI1 as well as GLI2-induced transcription, inhibits hedgehog with IC50 of 5 μM in GLI1 expressing HEK293T cell, displays selectivity over other pathways, such as TNF and glucocorticoid receptor gene transactivation.
• Target NameHedgehog/Smoothened inhibitor
• CAS No. 500579-04-4
• Calculated MW 429.6
• Formulation C27H35N5
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CN(C)C1=CC=CC=C1CN1CCCN(CC2=CC=CC=C2N(C)C)C1C1=CC=NC=C1
  Pathways:GPCR/G Protein; Stem Cells
  Receptor:GLI1
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 12 mg/mL (27.93 mM)
  Appearance:Faint Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Lauth M, et al. Proc Natl Acad Sci, 2007, 104(20), 8455-8560

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting