• Product NameXL019
• Brief DescriptionInhibitors
• Purification99.23%
• Biological ActivityXL019 is a potent and selective JAK2 inhibitor with IC50 of 2.2 nM, exhibiting >50-fold selectivity over JAK1, JAK3 and TYK2. Phase 1.
• Target NameFLT inhibitor; JAK inhibitor; PDGFR inhibitor
• CAS No. 945755-56-6
• Calculated MW 444.53
• Formulation C25H28N6O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C1C[C@H](NC1)C(=O)NC2=CC=C(C=C2)C3=NC(=NC=C3)NC4=CC=C(C=C4)N5CCOCC5
  Pathways:Angiogenesis; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors; JAK/STAT signaling; Stem Cells
  Receptor:FLT3; JAK1; JAK2; JAK3; PDGFRβ
  Boling pt:
  Melting pt:
  Solubility:DMSO: 16 mg/mL (35.99 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Forsyth T, et al. Bioorg Med Chem Lett, 2012, 22(24), 7653-7658.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting