• Product NameCHIR98014
• Brief DescriptionInhibitors
• Purification99.04%
• Biological ActivityCHIR 98014 is a potent GSK-3α/β inhibitor with IC50 of 0.65 nM/0.58 nM in cell-free assays, with the ability to distinguish GSK-3 from its closest homologs Cdc2 and ERK2.
• Target NameGSK-3 inhibitor; S6 Kinase inhibitor
• CAS No. 556813-39-9
• Calculated MW 486.31
• Formulation C20H17Cl2N9O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:NC1=C(C=CC(NCCNC2=NC=C(C3=NC=CN3)C(=N2)C2=C(Cl)C=C(Cl)C=C2)=N1)[N+]([O-])=O
  Pathways:PI3K/Akt/mTOR signaling; Stem Cells
  Receptor:GSK-3α/β; p70 S6K
  Boling pt:
  Melting pt:
  Solubility:DMSO: 8 mg/mL;Water: <1 mg/mL
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Ring DB,et al. Diabetes. 2003, 52(3), 588-595.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting