• Product NameFLI-06
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivityFLI-06 is a novel inhibitor of Notch signaling with EC50 of 2.3 μM.
• Target NameGamma-secretase inhibitor
• CAS No. 313967-18-9
• Calculated MW 438.52
• Formulation C25H30N2O5
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC1=C(C(C2=CC=C(C=C2)[N+]([O-])=O)C2=C(CC(C)(C)CC2=O)N1)C(=O)OC1CCCCC1
  Pathways:Neuroscience; Proteases/Proteasome; Stem Cells
  Receptor:Notch
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 8 mg/mL (18.24 mM); DMSO: 88 mg/mL (200.67 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Kr?mer A, et al. Nat Chem Biol. 2013, 9(11), 731-738.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting