• Product NameEPZ004777
• Brief DescriptionInhibitors
• Purification99.32%
• Biological ActivityEPZ004777 is a potent, selective?DOT1L?inhibitor with?IC50?of 0.4 nM.
• Target NameHistone Methyltransferase inhibitor
• CAS No. 1338466-77-5
• Calculated MW 539.67
• Formulation C28H41N7O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC(C)N(CCCNC(=O)NC1=CC=C(C=C1)C(C)(C)C)C[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=CC4=C3N=CN=C4N)O)O
  Pathways:Chromatin/Epigenetic
  Receptor:DOT1L
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 100 mg/mL (185.29 mM); DMSO: 100 mg/mL (185.29 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Daigle SR, et al. Y Cell. 2011, 20(1), 53-65.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting