• Product Name2-Amino-6-mercaptopurine
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityThioguanine, a purine antimetabolite, inhibits DNMT1 activity through ubiquitin-targeted degradation, used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g., Crohn's disease, rheumatoid arthritis) and organ transplant recipients.
• Target NameDNA Methyltransferase inhibitor
• CAS No. 154-42-7
• Calculated MW 167.2
• Formulation C5H5N5S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:NC1=NC(=S)C2=C(N1)N=CN2
  Pathways:Chromatin/Epigenetic
  Receptor:DNMT1
  Boling pt:
  Melting pt:
  Solubility:Ethanol: <1 mg/mL (<1 mM); Water: <1 mg/mL (<1 mM); DMSO: <1 mg/mL (<1 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Krynetskaia NF, et al. FASEB J,2000, 14(14), 2339-2344.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting