• Product NameEPZ5676
• Brief DescriptionInhibitors
• Purification99.29%
• Biological ActivityEPZ-5676 is an S-adenosyl methionine (SAM) competitive inhibitor of protein methyltransferase DOT1L with Ki of 80 pM, demonstrating >37,000-fold selectivity against all other PMTs tested, inhibits H3K79 methylation in tumor. Phase 1.
• Target NameHistone Methyltransferase inhibitor
• CAS No. 1380288-87-8
• Calculated MW 562.71
• Formulation C30H42N8O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC(C)N(C[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C2N=CN=C3N)O)O)C4CC(C4)CCC5=NC6=C(N5)C=C(C=C6)C(C)(C)C
  Pathways:Chromatin/Epigenetic
  Receptor:DOT1L
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 92 mg/mL warmed (163.49 mM); DMSO: 100 mg/mL warmed (177.71 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Robert A. Protein methyltransferases in Y. AACR Annual Meeting, 2013.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting