• Product NameGSK J4 hydrochloride
• Brief DescriptionInhibitors
• Purification98.56%
• Biological ActivityGSK J4 HCl is a cell permeable prodrug of GSK J1, which is the first selective inhibitor of the H3K27 histone demethylase JMJD3 and UTX with IC50 of 60 nM in a cell-free assay and inactive against a panel of demethylases of the JMJ family.
• Target NameHistone Demethylase inhibitor
• CAS No. 1373423-53-0
• Calculated MW 453.96
• Formulation C24H27N5O2HCl
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CCOC(=O)CCNC1=NC(=NC(=C1)N1CCC2=CC=CC=C2CC1)C1=CC=CC=N1
  Pathways:Chromatin/Epigenetic
  Receptor:JMJD3
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 90 mg/mL warmed (198.25 mM); DMSO: 90 mg/mL warmed (198.25 mM)
  Appearance:YellowPowder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Kruidenier L, et al. Nature, 2012, 488(7411), 404-408.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting