• Product NamePFK-158
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityPFK-158 is a potent and selective inhibitor of PFKFB3 that is currently being investigated in a phase I study in patients with advanced solid malignancies.
• Target NameGlucokinase inhibitor
• CAS No. 1462249-75-7
• Calculated MW 328.29
• Formulation C18H11F3N2O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C1=CC(=CC2=C1C=CC(=N2)/C=C/C(=O)C3=CC=NC=C3)C(F)(F)F
  Pathways:Metabolism
  Receptor:PFKFB3
  Boling pt:
  Melting pt:
  Solubility:DMSO: > 30 mg/mL
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Rebecca Redman, et al. Y Res August 1, 2015 75; CT206.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting