• Product NameAlvelestat (AZD9668)
• Brief DescriptionInhibitors
• Purification99.87%
• Biological ActivityAlvelestat (AZD9668) is an oral, highly selective inhibitor of neutrophil elastase (NE) with IC50 and Ki of 12 nM and 9.4 nM, at least 600-fold more selective over other serine proteases. Phase 2.
• Target NameSerine Protease inhibitor
• CAS No. 848141-11-7
• Calculated MW 545.53
• Formulation C25H22F3N5O4S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CN1N=CC=C1C1=C(C)N(C2=CC=CC(=C2)C(F)(F)F)C(=O)C(=C1)C(=O)NCC1=NC=C(C=C1)S(C)(=O)=O
  Pathways:Proteases/Proteasome
  Receptor:neutrophil elastase; neutrophil elastase
  Boling pt:
  Melting pt:
  Solubility:DMSO: 100 mg/mL (183.3 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Stevens T, et al. J Pharmacol Exp Ther. 2011, 339(1), 313-320.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting