• Product NameSP600125
• Brief DescriptionInhibitors
• Purification97.63%
• Biological ActivitySP600125 is a broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 40 nM, 40 nM and 90 nM, respectively; 10-fold greater selectivity against MKK4, 25-fold greater selectivity against MKK3, MKK6, PKB, and PKCα, and 100-fold selectivity against ERK2, p38, Chk1, EGFR etc.
• Target NameAurora Kinase inhibitor; JNK inhibitor; Trk receptor inhibitor
• CAS No. 129-56-6
• Calculated MW 220.23
• Formulation C14H8N2O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:O=C1C2=C3C(NN=C3C3=CC=CC=C13)=CC=C2
  Pathways:Cell Cycle/Checkpoint; MAPK; Tyrosine Kinase/Adaptors; Chromatin/Epigenetic
  Receptor:Aurora A; JNK1; JNK2; JNK3; TrkA
  Boling pt:
  Melting pt:
  Solubility:DMSO: 44 mg/mL (199.79 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Bennett BL, et al. Proc Natl Acad Sci U S A, 2001, 98(24), 13681-13686.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting