• Product NamePRT 4165
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityInhibitor of Bmi1/Ring1A, subunits of the polycomb repressive complex 1 (PRC1); inhibits self-ubiquitination (IC50?= 3.9?μM) but does not increase cellular levels of either subunit. Prevents Bmi1/Ring1A-mediated ubiquitination and drug-induced degradation of topoisomerase 2α?(Top2α).?
• Target NameBMI-1 inhibitor; Others inhibitor
• CAS No. 31083-55-3
• Calculated MW 235.24
• Formulation C15H9NO2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:C1=CC=C2C(=C1)C(=O)C(=CC3=CN=CC=C3)C2=O
  Pathways:Others
  Receptor:BMI-1; Ring1A
  Boling pt:
  Melting pt:
  Solubility:Soluble in DMSO
  Appearance:Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Ismail, et al. J Biol Chem. 2013 Sep 13;288(37):26944-54.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting