• Product NameLY2835219 mesylate
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityLY2835219 is a potent and selective inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM in cell-free assays, respectively. Phase 3.
• Target NameCDK inhibitor
• CAS No. 1231930-82-7
• Calculated MW 602.7
• Formulation C27H32F2N8CH4O3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CS(O)(=O)=O.CCN1CCN(CC2=CN=C(NC3=NC=C(F)C(=N3)C3=CC4=C(N=C(C)N4C(C)C)C(F)=C3)C=C2)CC1
  Pathways:Cell Cycle/Checkpoint
  Receptor:CDK4; CDK6
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 24 mg/mL (39.82 mM); Water: 100 mg/mL (165.92 mM); DMSO: 83 mg/mL (137.71 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Sanchez-Martinez et al. Mol Y Ther, 2011,10(11 Suppl), Abstract nr B234.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting