• Product NameKM11060
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityKM11060 is a novel corrector of the F508del-CFTR trafficking defect. Corrects F508del-CFTR trafficking; increases the amount of functional CFTR at the plasma membrane (~75%). Shown to inhibit PDE5 activity.
• Target NameCFTR inhibitor
• CAS No. 774549-97-2
• Calculated MW 422.33
• Formulation C19H17Cl2N3O2S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:C1CN(CCN1C2=C3C=CC(=CC3=NC=C2)Cl)S(=O)(=O)C4=CC=C(C=C4)Cl
  Pathways:Membrane transporter/Ion channel
  Receptor:CFTR
  Boling pt:
  Melting pt:
  Solubility:Soluble in DMSO
  Appearance:Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Robert R, et al. Mol Pharmacol. 2008 Feb;73(2):478-89.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting