• Product NameMLN1117
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityMLN1117 (INK1117) is a p110 inhibitor which inhibits p110α, p110β, p110γ, p110δ with IC50 of 15 nM, 4.5μM, 1.9μM, 13.39μM respectively.
• Target NamemTOR inhibitor; PI3K inhibitor
• CAS No. 1268454-23-4
• Calculated MW 363.37
• Formulation C19H17N6O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C1COCCN1C(=O)C2=CN=C3N2C=C(C=C3)C4=CC5=C(C=C4)OC(=N5)N
  Pathways:PI3K/Akt/mTOR signaling
  Receptor:mTOR; p110α; p110β; p110γ; p110δ
  Boling pt:
  Melting pt:
  Solubility:DMSO: 6.4 mg/mL (Need ultrasonic or warming)
  Appearance:Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Yap TA, et al. Curr Opin Pharmacol. 2015 Aug;23:98-107.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting