• Product NameSMER28
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivitySMER28 is a small-molecule enhancer (SMER) of autophagy, inducing autophagy independently of rapamycin in mammalian cells via an mTOR-independent mechanism and prevented the accumulation of amyloid beta peptide.
• Target NameAutophagy activator
• CAS No. 307538-42-7
• Calculated MW 264.12
• Formulation C11H10BrN3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:C=CCNC1=NC=NC2=C1C=C(C=C2)Br
  Pathways:Autophagy
  Receptor:Autophagy
  Boling pt:
  Melting pt:
  Solubility:DMSO: 52 mg/mL (196.88 mM); Ethanol: 52 mg/mL (196.88 mM)
  Appearance:Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Renna M et al. J Biol Chem. 2010 Apr 9;285(15):11061-7.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting