• Product NameVX-11e
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityVX-11e is a potent, selective, and orally bioavailable inhibitor of ERK (Extracellular Signal-Regulated Kinase); antitumor agent.
• Target NameAurora Kinase inhibitor; CDK inhibitor; ERK inhibitor; FLT inhibitor; GSK-3 inhibitor
• CAS No. 896720-20-0
• Calculated MW 500.35
• Formulation C24H20Cl2FN5O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC1=CN=C(N=C1C2=CNC(=C2)C(=O)N[C@H](CO)C3=CC(=CC=C3)Cl)NC4=C(C=C(C=C4)F)Cl
  Pathways:Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Angiogenesis; MAPK; Chromatin/Epigenetic; Stem Cells; Tyrosine Kinase/Adaptors
  Receptor:Aurora A; CDK2; ERK2; FLT3; GSK-3
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10 mM
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Aronov AM, et al. J Med Chem. 2009 Oct 22;52(20):6362-8.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting