• Product NameR112
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityR112 is an ATP-competitive inhibitor of Syk kinase with a Ki of 96 nM. R112 inhibits Syk kinase activity with an IC50 of 226 nM.
• Target NameSyk inhibitor
• CAS No. 575474-82-7
• Calculated MW 312.3
• Formulation C16H13FN4O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Immunology
  SMILES:OC1=CC=CC(NC2=NC=C(F)C(NC3=CC(O)=CC=C3)=N2)=C1
  Pathways:Angiogenesis
  Receptor:Syk
  Boling pt:
  Melting pt:
  Solubility:DMSO: 40mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Rossi AB, et al. J Allergy Clin Immunol. 2006 Sep;118(3):749-55.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting