• Product NameNU2058?
• Brief DescriptionInhibitors
• Purification99.95%
• Biological ActivityNU2058 is a potent CDK inhibitor that has CDK2 IC(50)=17 microM and CDK1 IC(50)=26 microM. Inhibits growth of human tumor cells in vitro (mean GI50 = 13 μM). Also inhibits DNA topoisomerase II ATPase activity (IC50 = 300 μM).
• Target NameCDK inhibitor; Topoisomerase inhibitor
• CAS No. 161058-83-9
• Calculated MW 247.3
• Formulation C12H17N5O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C1CCC(CC1)COC2=NC(=NC3=C2NC=N3)N
  Pathways:Cell Cycle/Checkpoint; DNA Damage/DNA Repair
  Receptor:CDK1; CDK2; Topo II
  Boling pt:
  Melting pt:
  Solubility:DMSO: 32 mg/mL
  Appearance:Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Rigas AC, et al. Oncogene. 2007 Dec 6;26(55):7611-9.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting