• Product NameNS1643
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityNS1643 is a potent human ether-a-go-go related gene (hERG) KV11.1 channel activator (EC50 = 10.5 μM).
• Target NameEGFR inhibitor
• CAS No. 448895-37-2
• Calculated MW 380.24
• Formulation C15H10F6N2O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:OC1=C(NC(=O)NC2=C(O)C=CC(=C2)C(F)(F)F)C=C(C=C1)C(F)(F)F
  Pathways:Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
  Receptor:hERG
  Boling pt:
  Melting pt:
  Solubility:Ethanol:100 mM, DMSO: 25 mM
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Casis O, et al. Mol Pharmacol. 2006 Feb;69(2):658-65.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting