• Product NameRo 46-2005
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityRo 46-2005 is a novel synthetic non-peptide endothelin receptor antagonist, inhibits the specific binding of 125I-ET-1 to human vascular smooth muscle cells (ETA receptor) with IC50 of 220 nM.
• Target NameEndothelin Receptor antagonist
• CAS No. 150725-87-4
• Calculated MW 473.54
• Formulation C23H27N3O6S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cardiovascular System
  SMILES:COC1=CC=CC(OC2=C(NS(=O)(=O)C3=CC=C(C=C3)C(C)(C)C)N=CN=C2OCCO)=C1
  Pathways:GPCR/G Protein
  Receptor:ET-A; ET-B
  Boling pt:
  Melting pt:
  Solubility:DMSO: 30mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Breu V, et al. FEBS Lett. 1993 Nov 15;334(2):210-4.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting