• Product NameCVT-313
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityCVT-313(NG-26) is a potent, selective, reversible, and ATP-competitive inhibitor of CDK2 (IC50 = 0.5 uM for Cdk2/A and Cdk2/E; 4.2 uM for Cdk1/B; 215 uM for Cdk4/D1).
• Target NameCDK inhibitor
• CAS No. 199986-75-9
• Calculated MW 400.47
• Formulation C20H28N6O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:COC1=CC=C(CNC2=NC(=NC3=C2N=CN3C(C)C)N(CCO)CCO)C=C1
  Pathways:Cell Cycle/Checkpoint
  Receptor:CDK1; CDK2; CDK4
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Brooks EE, et al. J Biol Chem. 1997 Nov 14;272(46):29207-11.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting