• Product NameGNF-7
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityGNF-7 inhibits Bcr-Abl WT and Bcr-Abl T315I with IC50 of 133 nM and 61 nM, respectively.
• Target NameAChR inhibitor; Bcr-Abl inhibitor
• CAS No. 839706-07-9
• Calculated MW 547.53
• Formulation C28H24F3N7O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CN1C(=O)N(CC2=CN=C(NC3=CN=C(C)C=C3)N=C12)C1=C(C)C=CC(NC(=O)C2=CC(=CC=C2)C(F)(F)F)=C1
  Pathways:Angiogenesis; Neuroscience; Cytoskeletal Signaling
  Receptor:M351T; c-Abl; E255V; G250E; T315I
  Boling pt:
  Melting pt:
  Solubility:DMSO: 40mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Liang X, et al. J Med Chem. 2016 Mar 10;59(5):1984-2004.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting