• Product NameAMG-337
• Brief DescriptionInhibitors
• Purification99.90%
• Biological ActivityAMG-337 is a potent and highly selective small molecule ATP-competitive MET kinase inhibitor. AMG 337 inhibits MET kinase activity with an IC50 of < 5nM in enzymatic assays.
• Target Namec-Met/HGFR inhibitor
• CAS No. 1173699-31-4
• Calculated MW 463.46
• Formulation C23H22FN7O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C[C@H](C1=NN=C2N1C=C(C=C2F)C3=CN(N=C3)C)N4C=CC5=NC=C(C=C5C4=C)OCCOC
  Pathways:Tyrosine Kinase/Adaptors
  Receptor:Met; Met(H1094R); Met(M1250T); Met(V1092I); Met(Y1230H)
  Boling pt:
  Melting pt:
  Solubility:DMSO: 46mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Paul E. Hughes, et al. Y Res October 1, 2014 74; 728

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting