• Product NameAZD-3965
• Brief DescriptionInhibitors
• Purification98.03%
• Biological ActivityAZD3965 is a selective inhibitor of monocarboxylate transporter 1 (MCT1) with a binding affinity of 1.6 nM, is 6 fold selective over MCT2 and does not inhibit MCT4 at 10 μM.
• Target NameMonocarboxylate Transporter inhibitor
• CAS No. 1448671-31-5
• Calculated MW 515.51
• Formulation C21H24F3N5O5S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC1=C(C(=NN1)C(F)(F)F)CC2=C(C3=C(S2)N(C(=O)N(C3=O)C)C(C)C)C(=O)N4C[C@](CO4)(C)O
  Pathways:Membrane transporter/Ion channel
  Receptor:MCT1
  Boling pt:
  Melting pt:
  Solubility:DMSO: 36mg/mL
  Appearance:WhitePowder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1.Bola BM, et al. Mol Y Ther. 2014 Dec;13(12):2805-16.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting