• Product NamePKC-412(Midostaurin)
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityPKC412(Midostaurin; CGP41231; CGP41251) is a broad spectrum protein kinase inhibitor; inhibits conventional PKC isoforms (α, β, γ), PDFRβ, VEGFR2, Syk, PKCη, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR.
• Target NameOthers inhibitor; PKC inhibitor
• CAS No. 120685-11-2
• Calculated MW 570.64
• Formulation C35H30N4O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C[C@@]12[C@@H]([C@@H](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)N(C)C(=O)C9=CC=CC=C9)OC
  Pathways:Cytoskeletal Signaling; Others
  Receptor:PPK; PKCα; PKCβ1; PKCβ2; PKCγ
  Boling pt:
  Melting pt:
  Solubility:DMSO: 175.24 mM
  Appearance:WhitePowder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1.Fabbro D, et al. Pharmacol Ther, 1999, 82(2-3), 293-301.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting