• Product NameNVP-TNKS656
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityNVP-TNKS656(TNKS-656) is a highly potent, selective, and orally active TNKS2 inhibitor with IC50 of 6 nM; > 300 fold selectivity against PARP1 and PARP2.
• Target NamePPAR inhibitor
• CAS No. 1419949-20-4
• Calculated MW 494.58
• Formulation C27H34N4O5
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:COC1=CC=C(C=C1)C(=O)C1CCN(CC(=O)N(CC2CC2)CC2=NC(=O)C3=C(CCOC3)N2)CC1
  Pathways:Metabolism
  Receptor:TNKS2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 100 mg/mL (202.19 mM); Ethnol: 10 mg/mL warming (20.21 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Shultz MD, et al. J Med Chem. 2013, 56(16), 6495-6511.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting