• Product NameDisodium clodronate tetrahydrate
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityClodronic acid(INN) orclodronate disodium(USAN) is a first generation (non-nitrogenous)?bisphosphonate. It is an anti-osteoporotic drug approved for the prevention and treatment of?osteoporosis?in post-menopausal women and men to reduce vertebral fractures,hyperparathyroidism,hypercalcemia?in malignancy,multiple myeloma?and fracture related pain because of its potent anti-inflammatory and analgesic effects shown as a reduction in inflammatory markers like?IL-1β,?IL-6, and?TNF-alfa.
• Target NameIL Receptor; TNF inhibitor
• CAS No. 88416-50-6
• Calculated MW 360.92
• Formulation CH10Cl2Na2O10P2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Endocrine system
  SMILES:C(P(=O)(O)[O-])(P(=O)(O)[O-])(Cl)Cl.O.O.O.O.[Na+].[Na+]
  Pathways:Apoptosis; Immunology/Inflammation
  Receptor:IL-1β; IL-6; TNF-α
  Boling pt:
  Melting pt:
  Solubility:Soluble in Water
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Pennanen, Niina et al. Pharmaceutical Research. 12 (6): 916C922.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting