- Product NameApoptozole
- Brief DescriptionInhibitors
- Purification99.00%
- Biological ActivityApoptozole, also known as Apoptosis Activator VII, is a selective inhibitor of heat shock protein 70 (Hsp70; 65% inhibition at 200 ?M) that acts by blocking its ATPase activity. Apoptozole enhances immune responses to administered antigens. Treatment of mice with Apoptozole elicits production of antibodies with a high IgG2c/IgG1 ratio and stimulates the release of Th1 and Th2-type cytokines, suggesting that Apoptozole activates the Th1 and Th2 immune responses. The ATPase activities of Hsp70 and Hsc70 are known to be responsible for regulation of various biological processes.
- Target NameHSP inhibitor
- CAS No. 1054543-47-3
- Calculated MW 625.56
- Formulation C33H25F6N3O3
- Storage 3 years -20˚C powder;2 years -80˚C in solvent;
