• Product NameAT-406
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityAT-406, an orally active antagonist of multiple inhibitor of apoptosis proteins(IAP), inhibits progression of human ovarian Y binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, 50- to 100-fold higher affinities than the Smac AVPI peptide. Phase 1.
• Target NameApoptosis inducer inhibitor
• CAS No. 1071992-57-8
• Calculated MW 561.72
• Formulation C32H43N5O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C[C@@H](C(=O)N[C@H]1CN(CC[C@H]2CC[C@H](N2C1=O)C(=O)NC(C3=CC=CC=C3)C4=CC=CC=C4)C(=O)CC(C)C)NC.Cl
  Pathways:Apoptosis
  Receptor:Apoptosis protein
  Boling pt:
  Melting pt:
  Solubility:DMSO: 100 mg/mL (178.02 mM); Ethanol: 100 mg/mL (178.02 mM)
  Appearance:Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Melissa KB, et al. Y Biol Ther. 2012 Jul 1; 13(9): 804C811.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting