• Product NamePF-04418948
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityPotent EP2?receptor antagonist (IC50?= 16 nM for human EP2?receptors). Displays over 2000-fold selectivity for EP2?receptors over EP1, EP3, EP4, DP1?amd CRTH2?receptors; exhibits <30% binding at a diverse panel of GPCRs and ion channels at a concentration of 10?μM. Inhibits PGE2-induced increases in intracellular cAMP; reverses PGE2-invoked relaxation of mouse trachea (IC50?= 2.7 nM).
• Target NameProstaglandin Receptor inhibitor
• CAS No. 1078166-57-0
• Calculated MW 409.41
• Formulation C23H20FNO5
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Endocrine system
  SMILES:COC1=CC2=C(C=C1)C=C(C=C2)OCC3(CN(C3)C(=O)C4=CC=C(C=C4)F)C(=O)O
  Pathways:GPCR/G Protein
  Receptor:PGE2
  Boling pt:
  Melting pt:
  Solubility:Soluble in DMSO
  Appearance:White powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. af Forselles KJ, et al. Br J Pharmacol. 2011 Dec;164(7):1847-1856.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting