• Product NameGSK6853
• Brief DescriptionInhibitors
• Purification99.08%
• Biological ActivityGSK6853 is a potent (300 pM), soluble, cell active (20 nM), and highly selective inhibitor of the BRPF1 bromodomain, and demonstrated properties suitable for cellular and in vivo studies. The BRPF (Bromodomain and PHD Fingercontaining) protein family are important scaffolding proteins for assembly of MYST histone acetyltransferase complexes. BRPF1 (bromodomain and PHD finger containing protein 1) is involved in the epigenetic regulation of gene expression and have been implicated in human Y.
• Target NameEpigenetic Reader Domain inhibitor
• CAS No. 1910124-24-1
• Calculated MW 409.21
• Formulation C22H27N5O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:O=C(NC1=C(N2[C@H](C)CNCC2)C=C(N3C)C(N(C)C3=O)=C1)C4=CC=CC=C4OC
  Pathways:Chromatin/Epigenetic
  Receptor:BRPF1; BRPF2; BRPF3
  Boling pt:
  Melting pt:
  Solubility:DMSO: 29 mg/mL
  Appearance:Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Bamborough P, et al. ACS Med Chem Lett. 2016 May 9;7(6):552-7.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting