- Product NameAM-2394?
- Brief DescriptionInhibitors
- Purification99.62%
- Biological ActivityAM-2394 is a potent and selective Glucokinase agonist (GKA), which catalyzes the phosphorylation of glucose to glucose-6-phosphate. AM-2394 activates GK with an EC50 of 60 nM, increases the affinity of GK for glucose by approximately 10-fold, exhibits moderate clearance and good oral bioavailability in multiple animal models, and lowers glucose excursion following an oral glucose tolerance test in an ob/ob mouse model of diabetes.
- Target NameGlucokinase agonist
- CAS No. 1442684-77-6
- Calculated MW 423.19
- Formulation C22H25N5O4
- Storage 3 years -20˚C powder;2 years -80˚C in solvent;
