• Product NameSZL P1-41
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivitySkp2 inhibitor; thought to prevent assembly of Skp2-Skp1 complexes. Selectively suppresses Skp2 SCF E3 ligase activity but exhibits no effect on the activity of other SCF complexes. Also inhibits Skp2-mediated p27 and Akt ubiquitination?in vivo?and?in vitro. Suppresses the survival of Y cells and Y stem cells by triggering cell senescence and inhibiting glycolysis. Exhibits antitumor effects in multiple animal models and Y cell lines.
• Target NameOthers inhibitor
• CAS No. 222716-34-9
• Calculated MW 420.52
• Formulation C24H24N2O3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CCC1=C(C(=C2C(=C1)C(=O)C(=CO2)C3=NC4=CC=CC=C4S3)CN5CCCCC5)O
  Pathways:Others
  Receptor:Skp2
  Boling pt:
  Melting pt:
  Solubility:Soluble to 20 mM in 1eq. HCl and to 5 mM in DMSO with gentle warming
  Appearance:Orange Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Chan et al. Cell, 2013;154:556

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting