• Product NameAzd6738
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityAZD6738 is an orally active, and selective?ATR?kinase inhibitor with?IC50?of 1 nM. Phase 1/2.
• Target NameATM/ATR inhibitor
• CAS No. 1352226-88-0
• Calculated MW 412.51
• Formulation C20H24N6O2S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C[C@@H]1COCCN1C2=NC(=NC(=C2)C3(CC3)[S@](=N)(=O)C)C4=C5C=CNC5=NC=C4
  Pathways:DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
  Receptor:ATR
  Boling pt:
  Melting pt:
  Solubility:DMSO: 82 mg/mL (198.78 mM), Ethanol: 41 mg/mL warming (99.39 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Vendetti FP, et al. Oncotarget. 2015. doi: 10.18632/oncotarget.6247.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting