• Product NameAKT inhibitor VIII
• Brief DescriptionInhibitors
• Purification98.65%
• Biological ActivityAkti-1/2 is a highly selective?Akt1/Akt2?inhibitor with?IC50?of 58 nM/210 nM, respectively, about 36-fold selectivity for Akt1 over Akt3.
• Target NameAkt inhibitor
• CAS No. 612847-09-3
• Calculated MW 551.64
• Formulation C34H29N7O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:C1CN(CCC1N2C3=CC=CC=C3NC2=O)CC4=CC=C(C=C4)C5=NC6=CC7=C(C=C6N=C5C8=CC=CC=C8)N=CN7
  Pathways:Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
  Receptor:Akt1; Akt2; Akt3
  Boling pt:
  Melting pt:
  Solubility:DMSO: 22 mg/mL (39.88 mM)
  Appearance:Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Lindsley CW, et al. Bioorg Med Chem Lett. 2005, 15(3), 761-764.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting