• Product NameSelonsertib?
• Brief DescriptionInhibitors
• Purification95.04%
• Biological ActivitySelonsertib, also known as GS-4997, is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. GS-4997 targets and binds to the catalytic kinase domain of ASK1 in an ATP-competitive manner, thereby preventing its phosphorylation and activation. GS-4997 prevents the production of inflammatory cytokines, down-regulates the expression of genes involved in fibrosis, suppresses excessive apoptosis and inhibits cellular proliferation.
• Target NameASK inhibitor
• CAS No. 1448428-04-3
• Calculated MW 445.49
• Formulation C24H24FN7O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Metabolism
  SMILES:CC1=C(C=C(C(=C1)F)C(=O)NC2=CC=CC(=N2)C3=NN=CN3C(C)C)N4C=C(N=C4)C5CC5
  Pathways:Apoptosis
  Receptor:ASK1
  Boling pt:
  Melting pt:
  Solubility:DMSO: 36 mg/mL (80.8 mM); Ethanol:24 mg/mL (53.87 mM)
  Appearance:Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Lin JH, et al. Nephron. 2015, 129(1):29-33.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting