• Product NameNaloxegol oxalate
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityNaloxegol (NKTR-118 and AZ-13337019), is a peripherally-selective opioid antagonist for the treatment of opioid-induced constipation. It was approved in 2014 in adult patients with chronic, non-Y pain. Chemically, naloxegol is a pegylated (polyethylene glycol-modified) derivative of α-naloxol. Specifically, the 5-α-hydroxyl group of α-naloxol is connected via an ether linkage to the free hydroxyl group of a monomethoxy-terminated n=7 oligomer of PEG.
• Target NameP450 inhibitor
• CAS No. 1354744-91-4
• Calculated MW 741.828
• Formulation C36H55NO15
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Metabolism
  SMILES:COCCOCCOCCOCCOCCOCCOCCO[C@H]1CC[C@]2([C@H]3CC4=C5[C@]2([C@H]1OC5=C(C=C4)O)CCN3CC=C)O.C(=O)(C(=O)O)O
  Pathways:Metabolism
  Receptor:CYP3A
  Boling pt:
  Melting pt:
  Solubility:DMSO 40 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Bui K, et al. J Clin Pharmacol. 2016 Aug;56(8):1019-27.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting